Table 4.
SNPs associated with differential weight change (ILI–DSE) from year 1 to 4 among participants who lost 3% weight at year 1
| SNP | Chr | Closest gene | Minor allele | MAF, %a | Effect | βb | SE | p value | q valuec |
|---|---|---|---|---|---|---|---|---|---|
| rs2053156 | 17 | GRB2 | C | 27.67 | Interaction | −3.506 | 0.751 | 3.14E-06 | 0.034 |
| ILI | −0.744 | 0.361 | 3.92E-02 | ||||||
| DSE | 2.762 | 0.659 | 2.82E-05 | ||||||
|
| |||||||||
| rs959260 | 17 | GRB2 | G | 27.68 | Interaction | −3.504 | 0.751 | 3.21E-06 | 0.034 |
| ILI | −0.742 | 0.361 | 4.00E-02 | ||||||
| DSE | 2.762 | 0.659 | 2.82E-05 | ||||||
|
| |||||||||
| rs713685 | 22 | TIMP3 | A | 8.90 | Interaction | 4.858 | 1.045 | 3.43E-06 | 0.034 |
| ILI | 1.895 | 0.500 | 1.53E-04 | ||||||
| DSE | −2.963 | 0.917 | 1.25E-03 | ||||||
|
| |||||||||
| rs9302989 | 17 | GRB2 | G | 26.79 | Interaction | −3.562 | 0.776 | 4.52E-06 | 0.034 |
| ILI | −0.598 | 0.374 | 1.10E-01 | ||||||
| DSE | 2.964 | 0.680 | 1.33E-05 | ||||||
|
| |||||||||
| rs4804366 | 19 | INSR | G | 12.59 | Interaction | 4.039 | 0.957 | 2.50E-05 | 0.152 |
| ILI | 0.881 | 0.444 | 4.72E-02 | ||||||
| DSE | −3.158 | 0.848 | 1.99E-04 | ||||||
Chr = Chromosome.
a
MAF in the full sample.
b
Effects of each copy of the minor allele on within-arm weight change for ILI and DSE as well as differential weight change (ILI–DSE) from year 1 to 4 (in kg).
c
Ranking based on q values (FDR <20%).