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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: J Biochem Mol Toxicol. 2014 Aug 6;28(12):529–538. doi: 10.1002/jbt.21594

FIGURE 1.

FIGURE 1

17 β-Estradiol (E2) down-regulates Nrf2 in MCF-10A cells in a time- and dose-dependent manner. (A) Nrf2 mRNA expression levels in MCF-10A cells treated with 10, 50 or 100 nM E2 for 24 hr; (B) Nrf2 protein expression levels in MCF-10A cells treated with increased doses of E2 for 48 hr; (C) Nrf2 mRNA expression levels in MCF-10A cells treated with 50 nM E2 for up to 72 hr; and (D) Nrf2 protein expression levels in MCF-10A cells treated with 50 nM E2 for up to 72 hr.

‘*’ indicates p value ≤ 0.05 compared with respective controls.