Table 3. Generalized linear mixed model analysis predicting facial freckle level in children (2005 – 2008).

Predictor	Parameter
	Odds Ratio	95% CI	p
Intercept
high freckling	0.001	0.0001, 0.01	<0.001
medium freckling	0.07	0.01, 0.41	0.003
low freckling	0.43	0.13, 1.39	0.16
rs12913832
high freckling	3.40	1.50, 7.75	0.004
medium freckling	1.90	1.16, 3.09	0.01
low freckling	1.08	0.80, 1.44	0.62
MC1R
high freckling	17.65	8.07, 38.60	<0.001
medium freckling	4.51	2.77, 7.34	<0.001
low freckling	1.52	1.09, 2.11	0.01
Female gender
high freckling	1.10	0.39, 3.06	0.86
medium freckling	1.22	0.64, 2.34	0.55
low freckling	1.42	0.95, 2.11	0.09
Sun Protection Composite
high freckling	1.12	0.95, 1.31	0.17
medium freckling	1.00	0.64, 2.34	0.97
low freckling	1.00	0.95, 2.11	1.00
Water Vacations
high freckling	0.73	0.55, 0.97	0.03
medium freckling	0.99	0.84, 1.17	0.92
low freckling	1.02	0.92, 1.13	0.72
Chronic Exposure
high freckling	1.03	1.01, 1.06	0.01
medium freckling	1.02	1.00, 1.04	0.05
low freckling	1.01	1.00, 1.03	0.04
Sunburns
high freckling	1.38	1.17, 1.63	0.000
medium freckling	1.25	1.09, 1.43	0.001
low freckling	1.06	0.96, 1.18	0.23
MC1R*Water Vacations
high freckling	1.45	1.11, 1.88	0.01
medium freckling	1.04	0.86, 1.25	0.71
low freckling	0.92	0.79, 1.06	0.22

reference group = no freckles