Table 2.
Associations between NF1 and medical conditions overall and by age group.
| All subjects | <18 yearsa | ≥18 yearsa | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Conditionb | NF1 group N (%) | Non-NF1 group N (%) | ORb | 95% CI | NF1 group N (%) | Non-NF1 group N (%) | ORc | 95% CI | NF1 group N (%) | Non-NF1 group No (%) | ORc | 95% CI |
| Epilepsy | ||||||||||||
| No | 7,837 (94.4) | 84,644 (99.4) | 1.0 | Ref. | 3,943 (95.1) | 42,308 (99.4) | 1.0 | Ref. | 3,894 (93.7) | 42,336 (99.4) | 1.0 | Ref. |
| Yes | 467 (5.6) | 536 (0.6) | 7.3 | 6.4-8.3 | 204 (4.9) | 259 (0.6) | 5.6 | 4.6-6.9 | 263 (6.3) | 277 (0.7) | 8.4 | 7.1-10.1 |
| Migraine | ||||||||||||
| No | 7,843 (95.8) | 83,233 (98.8) | 1.0 | Ref. | 4,033 (97.4) | 42,284 (99.5) | 1.0 | Ref. | 3,810 (94.1) | 40,949 (98.1) | 1.0 | Ref. |
| Yes | 345 (4.2) | 1010 (1.2) | 2.6 | 2.2-2.9 | 108 (2.6) | 207 (0.5) | 3.9 | 3.0-5.1 | 237 (5.9) | 803 (1.9) | 2.1 | 1.8-2.5 |
| Headache (including migraine) | ||||||||||||
| No | 6,505 (87.6) | 77,586 (96.8) | 1.0 | Ref. | 3,446 (90.9) | 39,894 (98.2) | 1.0 | Ref. | 3,059 (84.2) | 37,692 (95.3) | 1.0 | Ref. |
| Yes | 921 (12.4) | 2,592 (3.2) | 2.9 | 2.6-3.1 | 347 (9.2) | 751(1.9) | 3.4 | 2.9-3.9 | 574 (15.8) | 1,841 (4.7) | 2.5 | 2.3-2.8 |
| Multiple sclerosis | ||||||||||||
| No | 8,527 (99.7) | 85,615 (99.9) | 1.0 | Ref. | 4,291 (100) | 42,916 (100) | ND | ND | 4,236 (99.4) | 42,699 (99.8) | 1.0 | Ref. |
| Yes | 25 (0.3) | 108 (0.1) | 1.9 | 1.2-2.9 | 0 (0.0) | 5 (0.01) | ND | ND | 25 (0.6) | 103 (0.2) | 1.9 | 1.2-3.0 |
| Parkinson's disease | ||||||||||||
| No | 8,562 (99.9) | 85,762 (100.0) | 1.0 | Ref. | 4,292 (100) | 42,927 (100) | ND | ND | 4,270 (99.8) | 42,835 (100) | 1.0 | Ref. |
| Yes | 7 (0.08) | 19 (0.02) | 3.1 | 1.3-7.5 | 0 (0.0) | 1 (0.0) | ND | ND | 7 (0.2) | 18 (0.04) | 3.3 | 1.4-7.9 |
| Sleep disturbances/disorder | ||||||||||||
| No | 7,842 (96.2) | 82,029 (98.2) | 1.0 | Ref. | 4,139 (98.8) | 42,298 (99.6) | 1.0 | Ref. | 3,703 (93.4) | 39,731 (96.7) | 1.0 | Ref. |
| Yes | 311 (3.8) | 1,499 (1.8) | 1.4 | 1.2-2.6 | 49 (1.2) | 155 (0.4) | 1.8 | 1.2-2.5 | 262 (6.6) | 1,344 (3.3) | 1.4 | 1.2-1.6 |
| Acute urinary infection | ||||||||||||
| No | 7,408 (86.4) | 77,735 (90.6) | 1.0 | Ref. | 3,964 (92.3) | 40,136 (93.5) | 1.0 | Ref. | 3,444 (80.4) | 37,599 (87.7) | 1.0 | Ref. |
| Yes | 1,171 (13.7) | 8,055 (9.4) | 1.0 | 0.96-1.1 | 329 (7.7) | 2794 (6.5) | 0.7 | 0.6-0.8 | 842 (19.7) | 5,261 (12.3) | 1.2 | 1.1-1.3 |
| Diabetesd | ||||||||||||
| No | 8,220 (97.6) | 81,473 (96.3) | 1.0 | Ref. | 4268 (99.8) | 42714 (99.7) | 1.0 | Ref. | 3,952 (95.3) | 38,759 (92.7) | 1.0 | Ref. |
| Yes | 201 (2.4) | 3,167 (3.7) | 0.4 | 0.3-0.4 | 7 (0.2) | 126 (0.3) | 0.3 | 0.1-0.6 | 194 (4.7) | 3,041 (7.3) | 0.4 | 0.3-0.4 |
OR, odds ratio; CI, confidence interval; NF1, Neurofibromatosis Type 1; ND, Not Determined
a
Age on 1/1/2006 or at enrollment if birth occurred after 1/1/2006
b
Individuals with only one ICD-9-CM code for the medical condition during the study period were excluded from the analysis
c
Adjusted for age, enrollment time, number of healthcare visits, and sex
d
Includes Diabetes types I and II