Table 3.
Differences in sex and mean age at for first healthcare claim between the NF1 and non-NF1 groups by medical condition.
| Females with medical condition | Age at first healthcare claim for conditiona | |||||
|---|---|---|---|---|---|---|
| Medical condition (Number of cases in NF1/non-NF1 group, respectively) | NF1 group (% female)b | Non-NF1 group (% female)b | P-valuec | NF1 group mean (SD) | Non-NF1 group mean (SD) | P-valuee |
| Epilepsy (467, 536) | 48.8 | 50.8 | 0.5433 | 27.1 (18.5) | 27.6 (19.7) | 0.9806 |
| Headache (including migraine) (921, 2592) | 64.6 | 73.2 | <0.0001 | 29.9 (17.3) | 34.2 (16.7) | <0.0001 |
| Migraine (345, 1010) | 71.2 | 74.5 | 0.1324 | 31.0 (15.5) | 36.4 (15.4) | <0.0001 |
| Multiple sclerosis (25, 108) | 60.0 | 78.7 | 0.0510 | 45.2 (10.4) | 44.9 (12.4) | 0.9039 |
| Parkinson's disease (7, 19) | 42.9 | 47.4 | 1.0d | 56.0 (5.2) | 53.9 (12.5) | 0.9771 |
| Sleep disturbances/disorder (311, 1499) | 47.3 | 46.4 | 0.7715 | 41.2 (17.4) | 44.4 (15.4) | 0.0416 |
| UTI (1171, 8055) | 77.5 | 84.5 | <0.0001 | 35.2 (19.4) | 32.4 (19.4) | <0.0001 |
| Diabetes (201, 3167) | 50.3 | 48.9 | 0.7194 | 50.4 (12.0) | 50.2 (11.8) | 0.6566 |
N, number; NF1, neurofibromatosis type 1; SD, standard deviation
a
Age was estimated as the difference between the year of the healthcare claim for the condition during 2006-2010 and the patient's birth year
b
Percent female in NF1/non-NF1 group in those with medical condition listed in column 1.
c
Chi-square test p-value
d
Fisher's exact test two-sided p-value
e
Based on Wilcoxon Two-sample Test (T-approximation)