Table 3. Linear mixed-effect model to determine variables that influence rivaroxaban concentration.

Variable		Adjusted Estimate (95%CI)	P value
Congestive heart failure	No	Reference	0.482
	Yes	0.07 (−0.11 to 0.23)
Diabetes mellitus	No	Reference	0.029
	Yes	0.13 (0.01 to 0.25)
NIHSS score, per 1 point		−0.01(−0.02 to 0.01)	0.346
Rivaroxaban dosage	15 mg QD	Reference	0.146
	10 mg QD	−0.08 (−0.19 to 0.03)
Tablet crushing	No	Reference	<0.001
	Yes	−0.43 (−0.60 to −0.26)
Time from stroke/TIA onset to blood sampling, per day		−0.02 (−0.03 to 0.01)	0.047
Time points of blood sampling	0 h	Reference
	4 h	1.13 (1.06 to 1.20)	<0.001
	9 h	0.29 (0.22 to 0.37)	<0.001

NIHSS, National Institutes of Health Stroke Scale; TIA, transient ischemic attack.