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. 2014 Nov 26;13:254. doi: 10.1186/1476-4598-13-254

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© Chen et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Smad4 regulates MMP7 expression in OSCCs. (A) Quantitative RT-PCR expression of the MMP-7 gene in OECM1 and HSC3 cell lines with or without siSmad4. (B) Western blotting revealed the expression levels of MMP7 in OSCC cells with or without siSmad4. (C) MMP7 concentrations and activity in OECM1 and HSC3 media were assessed by ELISA and casein zymography, respectively. Cell culture media were collected and concentrated from Smad4 silencing OSCC cell lines. Each data point represents the mean ± SD of at least three independent experiments. The asterisk indicates as statistically the significant difference (*, p <0.05) compared to control.