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. 2014 Nov 26;13:254. doi: 10.1186/1476-4598-13-254

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© Chen et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Schematic representation of SIRT1 effects on metastasis of oral cancer. SIRT1 reduced cell migration and invasion in oral cancer by deacetylating Smad4 and repressing the effect of TGF-β signaling on MMP7.