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. 2014 Oct 30;45(1):107. doi: 10.1186/s13567-014-0107-6

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© Richard-Mazet et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Study 1 Kinetics of HI antibody titers induced by different vaccines. Mean HI titers (log2) using (A) H5N1 clade 1 (NIBRG14) and (B) H5N9 antigens in the serum of five groups of vaccinated chickens. One group of SPF chickens was vaccinated with 3 log10 of vFP2211. The four other groups had H5N9 and FP MDA and were vaccinated either with 3 or 5 log10 of vFP2211 at D0, with inH5N9 at D21, or with 5 log10 of vFP2211 at D0 followed by inH5N9 at D21 (prime-boost). HI titers were evaluated at D0, D21 (3 weeks after the vaccination with vFP2211), D42 and D84 (3 and 9 weeks, respectively, after the 2^nd vaccination with inH5N9 in the prime-boost group).