Table 1.
Genotype distribution of glutamate receptor family gene SNPs in Taiwanese KD patients and controls
| SNP | Chromosome | Cytoband | Physical position | Nearest genes | Controls | KD patients | |||
|---|---|---|---|---|---|---|---|---|---|
| No. (%) | No. (%) | pvalue | Odds ratio (95% CI) | ||||||
| rs466013 | 21 | q21.3 | 29826390 | GRIK1 | TT + TC | 507 (45.9) | 131 (50.2) | 0.205 | 1.19 (0.91-1.56) |
| CC | 599 (54.1) | 130 (49.8) | 1 | ||||||
| rs425507 | 21 | q21.3 | 29827658 | GRIK1 | GG + GA | 507(45.8) | 130 (49.6) | 0.265 | 1.17 (0.89-1.53) |
| AA | 600 (54.2) | 132 (50.4) | 1 | ||||||
| rs388700 | 21 | q21.3 | 29830158 | GRIK1 | TT + TA | 506 (45.7) | 130 (49.6) | 0.254 | 1.17 (0.89-1.53) |
| AA | 601 (54.3) | 132 (50.4) | 1 | ||||||
| rs402280 | 21 | q21.3 | 29835401 | GRIK1 | TT + TA | 424 (38.3) | 116 (44.3) | 0.075 | 1.28 (0.97-1.68) |
| AA | 683 (61.7) | 146 (55.7) | 1 | ||||||
| rs17816480 | 6 | q16.3 | 101522140 | GRIK2 | TT + TC | 201 (18.2) | 48 (18.3) | 0.951 | 1.01 (0.71-1.43) |
| CC | 906 (81.8) | 214 (81.7) | 1 | ||||||
| rs2786239 | 6 | q16.3 | 101637565 | GRIK2 | GG + GA | 186 (16.8) | 45 (17.2) | 0.885 | 1.03 (0.72-1.47) |
| AA | 921 (83.2) | 217 (82.8) | |||||||
| rs4840194 | 6 | q16.3 | 101768497 | GRIK2 | CC + CT | 357 (32.2) | 88 (33.6) | 0.677 | 1.06 (0.80-1.41) |
| TT | 750 (67.8) | 174 (66.4) | 1 | ||||||
| rs1310715 | 6 | q16.3 | 101961427 | GRIK2 | TT + TC | 597 (53) | 133 (50.9) | 0.468 | 0.91 (0.69-1.91) |
| CC | 520 (47.0) | 128 (49.1) | 1 | ||||||
| rs527631 | 1 | p34.3 | 36844396 | GRIK3 | AA + AG | 172 (15.5) | 45 (17.6) | 0.407 | 1.16 (0.81-1.67) |
| GG | 935 (84.5) | 210 (82.4) | 1 | ||||||
| rs476894 | 1 | p34.3 | 36868682 | GRIK3 | GG + GA | 234 (21.1) | 63 (24.0) | 0.305 | 1.18 (0.86-1.62) |
| AA | 873 (78.9) | 199 (76.0) | 1 | ||||||
| rs541671 | 1 | p34.3 | 36905238 | GRIK3 | TT + TA | 267 (24.1) | 65 (25.9) | 0.554 | 1.10 (0.80-1.51) |
| AA | 840 (75.9) | 186 (74.1) | 1 | ||||||
| rs35317705 | 1 | p34.3 | 36972969 | GRIK3 | CC + CT | 128 (11.6) | 33 (12.6) | 0.641 | 1.10 (0.73-1.66) |
| TT | 979 (88.4) | 229 (87.4) | 1 | ||||||
| rs11218005 | 11 | q23.3 | 120782227 | GRIK4 | AA + AC | 132 (11.9) | 35 (13.4) | 0.523 | 1.14 (0.76-1.70) |
| CC | 975 (88.1) | 227 (86.6) | 1 | ||||||
| rs3901285 | 11 | q23.3 | 120862726 | GRIK4 | TT + TC | 650 (58.7) | 158 (60.3) | 0.638 | 1.07 (0.81-1.41) |
| CC | 457 (41.3) | 104 (39.7) | 1 | ||||||
| rs4936566 | 11 | q23.3 | 120944529 | GRIK4 | AA + AG | 669 (60.4) | 145 (55.3) | 0.131 | 0.81 (0.62-1.06) |
| GG | 438 (39.6) | 117 (44.7) | 1 | ||||||
| rs443239 | 19 | q13.2 | 42001892 | GRIK5 | CC + CG | 289 (26.1) | 64 (24.4) | 0.576 | 0.91 (0.67-1.25) |
| GG | 818 (73.9) | 198 (75.6) | 1 | ||||||
| rs1493395 | 5 | q33.2 | 153532297 | GRIA1 | AA + AG | 565 (51.1) | 125 (47.7) | 0.326 | 0.87 (0.67-1.14) |
| GG | 541 (48.9) | 137 (52.3) | 1 | ||||||
| rs12153489 | 5 | q33.2 | 153568777 | GRIA1 | CC + CT | 1087 (98.2) | 259 (98.9) | 0.454 | 1.59 (0.47-5.39) |
| TT | 20 (1.8) | 3 (1.1) | 1 | ||||||
| rs4424038 | 5 | q33.2 | 153740704 | GRIA1 | CC + CT | 1102 (99.5) | 262 (100.0) | 0.276 | ND |
| TT | 5 (0.5) | 0 (0.0) | 1 | ||||||
| rs17035909 | 4 | q32.1 | 157247565 | GRIA2 | AA + AT | 351 (31.7) | 87 (33.3) | 0.640 | 1.07 (0.80-1.43) |
| TT | 756 (68.3) | 175 (66.7) | 1 | ||||||
| rs17035959 | 4 | q32.1 | 157302204 | GRIA2 | AA + AC | 1075 (97.1) | 255 (97.3) | 0.848 | 1.08 (0.47-2.48) |
| CC | 32 (2.9) | 7 (2.7) | 1 | ||||||
| rs7695870 | 4 | q32.1 | 157342624 | GRIA2 | CC + CT | 1082 (97.7) | 258 (98.5) | 0.460 | 1.49 (0.51-4.32) |
| TT | 25 (2.3) | 4 (1.5) | 1 | ||||||
| rs6855973 | 4 | q32.1 | 157365463 | GRIA2 | AA + AT | 1085 (98) | 258 (98.4) | 0.623 | 1.31 (0.45-3.83) |
| TT | 22 (2.0) | 4 (1.6) | 1 | ||||||
| rs10895875 | 11 | q22.3 | 105785485 | GRIA4 | AA + AT | 715 (64.6) | 181 (69.1) | 0.169 | 1.23 (0.92-1.64) |
| TT | 392 (35.4) | 81 (30.9) | 1 | ||||||
| rs4754136 | 11 | q22.3 | 105846312 | GRIA4 | CC + CT | 1102 (99.5) | 261 (99.6) | 0.877 | 1.18 (0.14-10.18) |
| TT | 5 (0.5) | 1 (0.4) | 1 | ||||||
| rs17104835 | 11 | q22.3 | 105971356 | GRIA4 | CC + CT | 447 (40.4) | 104 (39.8) | 0.839 | 0.97 (0.74-1.28) |
| TT | 660 (59.6) | 158 (60.2) | 1 | ||||||
| rs7750018 | 6 | q24.3 | 146206595 | GRM1 | CC + CT | 285 (25.7) | 62 (23.7) | 0.486 | 0.89 (0.65-1.23) |
| TT | 822 (74.3) | 200 (76.3) | 1 | ||||||
| rs362851 | 6 | q24.3 | 146389448 | GRM1 | CC + CG | 713 (64.4) | 169 (64.5) | 0.977 | 1.00 (0.76-1.33) |
| GG | 394 (35.6) | 93 (35.5) | 1 | ||||||
| rs2300631 | 6 | q24.3 | 146428918 | GRM1 | AA + AG | 828 (74.8) | 192 (63.3) | 0.613 | 0.92 (0.68-1.25) |
| GG | 279 (25.2) | 70 (26.7) | 1 | ||||||
| rs12023603 | 3 | p21.2 | 51466999 | GRM2 | AA + AG | 1076 (97.2) | 253 (96.6) | 0.583 | 0.81 (0.38-1.72) |
| GG | 31 (2.8) | 9 (3.4) | 1 | ||||||
| rs1983842 | 3 | p21.2 | 51535259 | GRM2 | AA + AG | 1070 (96.7) | 253 (96.6) | 0.940 | 0.97 (0.46-2.04) |
| GG | 37 (3.3) | 9 (3.4) | 1 | ||||||
| rs802441 | 7 | q21.11 | 86657787 | GRM3 | CC + CT | 1081 (97.6) | 255 (97.3) | 0.759 | 0.88 (0.38-2.04) |
| TT | 26 (2.4) | 7 (2.7) | 1 | ||||||
| rs802466 | 7 | q21.11 | 86698122 | GRM3 | CC + CT | 222 (20.0) | 44 (16.8) | 0.230 | 0.80 (0.56-1.15) |
| TT | 885 (80.0) | 218 (83.2) | |||||||
| rs12704286 | 7 | q21.11 | 86745625 | GRM3 | AA + AG | 364 (32.9) | 91 (34.8) | 0.567 | 1.09 (0.82-1.44) |
| GG | 743 (67.1) | 171 (65.2) | 1 | ||||||
| rs17697415 | 7 | q21.11 | 86772500 | GRM3 | AA + AG | 138 (12.5) | 34 (13.0) | 0.822 | 1.05 (0.70-1.57) |
| GG | 969 (87.5) | 228 (87.0) | 1 | ||||||
| rs1873254 | 6 | p21.31 | 34058712 | GRM4 | AA + AG | 518 (55.9) | 150 (57.4) | 0.096 | 1.26 (0.96-1.66) |
| GG | 488 (44.1) | 112 (42.6) | 1 | ||||||
| rs937039 | 6 | p21.31 | 34075875 | GRM4 | AA + AG | 1090 (98.5) | 260 (99.2) | 0.337 | 2.03 (0.47-8.83) |
| GG | 17 (1.5) | 2 (0.8) | 1 | ||||||
| rs1565361 | 6 | p21.31 | 34089248 | GRM4 | CC + CT | 503 (45.5) | 117 (44.7) | 0.819 | 0.97 (0.74-1.27) |
| TT | 604 (54.5) | 145 (55.3) | 1 | ||||||
| rs4106126 | 11 | q14.2 | 88647181 | GRM5 | CC + CT | 1093 (98.7) | 256 (97.7) | 0.214 | 0.55 (0.21-1.44) |
| TT | 14 (1.3) | 6 (2.3) | 1 | ||||||
| rs1391878 | 11 | q14.2 | 88713212 | GRM5 | CC + CT | 264 (23.9) | 58 (22.1) | 0.557 | 0.91 (0.66-1.25) |
| TT | 843 (76.1) | 204 (77.9) | 1 | ||||||
| rs12787863 | 11 | q14.2 | 88810547 | GRM5 | AA + AG | 447 (40.4) | 110 (42.0) | 0.634 | 1.07 (0.81-1.40) |
| GG | 660 (59.6) | 152 (58.0) | 1 | ||||||
| rs7126679 | 11 | q14.2 | 89020677 | GRM5 | AA + AG | 651 (58.9) | 160 (61.1) | 0.513 | 1.10 (0.83-1.44) |
| GG | 455 (41.1) | 102 (38.9) | 1 | ||||||
| rs2856354 | 5 | q35.3 | 178978728 | GRM6 | AA + AG | 1055 (95.3) | 244 (93.1) | 0.151 | 0.67 (0.38-1.16) |
| GG | 52 (4.7) | 18 (6.9) | 1 | ||||||
| rs10464073 | 5 | q35.3 | 178982284 | GRM6 | AA + AG | 1056 (95.4) | 244 (93.1) | 0.132 | 0.65 (0.38-1.14) |
| GG | 51 (4.6) | 18 (6.9) | 1 | ||||||
| rs17078880 | 5 | q35.3 | 178983436 | GRM6 | CC + CT | 1089 (98.4) | 258 (98.5) | 0.908 | 1.07 (0.36-3.18) |
| TT | 18 (1.6) | 4 (1.5) | 1 | ||||||
| rs2645341 | 5 | q35.3 | 178984314 | GRM6 | AA + AG | 1087 (98.2) | 258 (98.5) | 0.756 | 1.19 (0.40-3.50) |
| GG | 20 (1.8) | 4 (1.5) | 1 | ||||||
| rs6764411 | 3 | p26.1 | 7101864 | GRM7 | AA + AC | 927 (83.8) | 211 (80.5) | 0.202 | 0.80 (0.57-1.13) |
| CC | 179 (16.2) | 51 (19.5) | 1 | ||||||
| rs17697928 | 3 | p26.1 | 7326084 | GRM7 | AA + AG | 861 (77.7) | 199 (80) | 0.525 | 0.90 (0.66-1.24) |
| GG | 246 (22.3) | 51 (19.5) | 1 | ||||||
| rs779741 | 3 | p26.1 | 7541915 | GRM7 | AA + AC | 917 (82.8) | 218 (83.2) | 0.886 | 1.03 (0.72-1.47) |
| CC | 190 (17.2) | 44 (16.8) | 1 | ||||||
| rs1354405 | 3 | p26.1 | 7690304 | GRM7 | AA + AG | 1012 (91.4) | 236 (90.1) | 0.491 | 0.85 (0.54-1.34) |
| GG | 95 (8.6) | 26 (9.9) | 1 | ||||||
| rs712723 | 7 | q31.33 | 126439090 | GRM8 | CC + CT | 698 (63.0) | 174 (66.4) | 0.309 | 1.16 (0.87-1.54) |
| TT | 409 (37.0) | 88 (33.6) | 1 | ||||||
| rs17627206 | 7 | q31.33 | 126793483 | GRM8 | AA + AG | 110 (9.9) | 28 (10.7) | 0.717 | 1.08 (0.70-1.68) |
| GG | 997 (90.1) | 234 (89.3) | 1 | ||||||
| rs11563505 | 7 | q31.33 | 127059729 | GRM8 | CC + CT | 1086 (98.1) | 258 (98.5) | 0.687 | 1.25 (0.42-3.66) |
| TT | 21 (1.9) | 4 (1.5) | 1 | ||||||
GRIK, glutamate receptor, ionotropic, kainate; GRIA, glutamate receptor, ionotropic, AMPA; GRM, glutamate receptor, metabotropic, SNP, single nucleotide polymorphism; CI, confidence interval.
p-values were obtained by chi-square test (2 x 2 table).
Statistical significance was considered as p value <0.05.
Physical position of individual SNPs was based on the NCBI Assembly database: GRCH38 version.