Table 2.
Association of the genetic variants of glutamate receptor family genes in Taiwanese KD children according to the presence or absence of CAA
| SNP | Chromosome | Cytoband | Physical position | Nearest genes | KD CAA- | KD CAA+ | |||
|---|---|---|---|---|---|---|---|---|---|
| No. (%) | No. (%) | pvalue | Odds ratio (95% CI) | ||||||
| rs466013 | 21 | q21.3 | 29826390 | GRIK1 | TT + TC | 83 (44.9) | 48 (63.2) | 0.007 | 2.11 ( 1.22-3.65 ) |
| CC | 102 (55.1) | 28 (36.8) | 1 | ||||||
| rs425507 | 21 | q21.3 | 29827658 | GRIK1 | G + GA | 82 (44.1) | 48 (63.2) | 0.01 | 2.17 ( 1.26-3.76 ) |
| AA | 104 (55.9) | 28 (36.8) | 1 | ||||||
| rs388700 | 21 | q21.3 | 29830158 | GRIK1 | TT + TA | 81 (44.1) | 48 (63.2) | 0.004 | 2.20 ( 1.27-3.81 ) |
| AA | 104 (55.9) | 28 (36.8) | 1 | ||||||
| rs402280 | 21 | q21.3 | 29835401 | GRIK1 | TT + TA | 74 (39.8) | 42 (55.2) | 0.022 | 1.87 ( 1.09-3.21 ) |
| AA | 112 (60.2) | 34 (44.8) | 1 | ||||||
| rs17816480 | 6 | q16.3 | 101522140 | GRIK2 | TT + TC | 30 (16.1) | 18 (23.7) | 0.151 | 1.61 (0.84-3.11) |
| CC | 156 (83.9) | 58 (76.3) | 1 | ||||||
| rs2786239 | 6 | q16.3 | 101637565 | GRIK2 | GG + GA | 29 (15.6) | 16 (21.1) | 0.288 | 1.44 (0.73-2.85) |
| AA | 157 (84.4) | 60 (78.9) | 1 | ||||||
| rs4840194 | 6 | q16.3 | 101768497 | GRIK2 | CC + CT | 64 (34.4)) | 24 (31.6) | 0.660 | 0.88 (0.50-1.56) |
| TT | 122 (65.6) | 52 (68.4) | 1 | ||||||
| rs1310715 | 6 | q16.3 | 101961427 | GRIK2 | TT + TC | 91 (49.2) | 42 (55.3) | 0.373 | 1.28 (0.75-2.18) |
| CC | 94 (50.8) | 34 (44.7) | 1 | ||||||
| rs527631 | 1 | p34.3 | 36844396 | GRIK3 | AA + AG | 32 (17.6) | 13 (17.8) | 0.966 | 1.02 (0.50-2.07) |
| GG | 150 (82.4) | 60 (82.2) | 1 | ||||||
| rs476894 | 1 | p34.3 | 36868682 | GRIK3 | GG + GA | 45 (24.2) | 18 (23.7) | 0.930 | 0.97 (0.52-1.82) |
| AA | 141 (75.8) | 58 (76.3) | 1 | ||||||
| rs541671 | 1 | p34.3 | 36905238 | GRIK3 | TT + TA | 47 (26.1) | 18 (25.3) | 0.902 | 0.96 (0.51-1.80) |
| AA | 133 (73.9) | 53 (74.7) | 1 | ||||||
| rs35317705 | 1 | p34.3 | 36972969 | GRIK3 | CC + CT | 22 (11.8) | 11 (14.5) | 0.558 | 1.26 (0.58-2.75) |
| TT | 164 (88.2) | 65 (85.5) | 1 | ||||||
| rs11218005 | 11 | q23.3 | 120782227 | GRIK4 | AA + AC | 27 (14.5) | 8 (10.5) | 0.389 | 0.69 (0.30-1.60) |
| CC | 159 (85.5) | 68 (89.5) | 1 | ||||||
| rs3901285 | 11 | q23.3 | 120862726 | GRIK4 | TT + TC | 113 (60.7) | 45 (59.2) | 0.817 | 0.94 (0.54-1.62) |
| CC | 73 (39.3) | 31 (40.8) | 1 | ||||||
| rs4936566 | 11 | q23.3 | 120944529 | GRIK4 | AA + AG | 104 (55.9) | 41 (54.0) | 0.771 | 0.92 (0.54-1.58) |
| GG | 82 (44.1) | 35 (46.0) | 1 | ||||||
| rs443239 | 19 | q13.2 | 42001892 | GRIK5 | CC + CG | 45 (24.2) | 19 (25.0) | 0.890 | 1.04 (0.56-1.94) |
| GG | 141 (75.8) | 57 (75.0) | 1 | ||||||
| rs1493395 | 5 | q33.2 | 153532297 | GRIA1 | AA + AG | 88 (47.3) | 37 (48.7) | 0.840 | 1.06 (0.62-1.80) |
| GG | 98 (52.7) | 39 (51.3) | 1 | ||||||
| rs12153489 | 5 | q33.2 | 153568777 | GRIA1 | TT + CT | 40 (21.5) | 19 (25.0) | 0.539 | 1.22 (0.65-2.28) |
| CC | 146 (78.5) | 57 (75.0) | 1 | ||||||
| rs4424038 | 5 | q33.2 | 153740704 | GRIA1 | TT + CT | 23 (12.4) | 10 (13.2) | 0.861 | 1.07 (0.48-2.38) |
| CC | 163 (87.6) | 66 (86.8) | 1 | ||||||
| rs17035909 | 4 | q32.1 | 157247565 | GRIA2 | AA + AT | 66 (35.7) | 21 (27.6) | 0.210 | 0.69 (0.38-1.24) |
| TT | 119 (64.3) | 55 (72.4) | 1 | ||||||
| rs17035959 | 4 | q32.1 | 157302204 | GRIA2 | CC + AC | 72 (38.7) | 25 (32.9) | 0.376 | 0.78 (0.44-1.36) |
| AA | 114 (61.3) | 51 (67.1) | 1 | ||||||
| rs7695870 | 4 | q32.1 | 157342624 | GRIA2 | TT + CT | 50 (26.9) | 26 (34.2) | 0.236 | 1.41 (0.80-2.51) |
| CC | 136 (73.1) | 50 (65.8) | 1 | ||||||
| rs6855973 | 4 | q32.1 | 157365463 | GRIA2 | TT + AT | 60 (33.2) | 18 (24.0) | 0.148 | 0.64 (0.34-1.18) |
| AA | 121 (66.8) | 57 (76.0) | 1 | ||||||
| rs10895875 | 11 | q22.3 | 105785485 | GRIA4 | AA + AT | 130 (69.9) | 51 (67.1) | 0.673 | 1.16 (0.58-2.30) |
| TT | 56 (30.1) | 25 (32.9) | 1 | ||||||
| rs4754136 | 11 | q22.3 | 105846312 | GRIA4 | TT + CT | 26(14.0) | 5 (6.6) | 0.092 | 0.43 (0.16-1.17) |
| CC | 160 (86.0) | 71 (93.4) | 1 | ||||||
| rs17104835 | 11 | q22.3 | 105971356 | GRIA4 | CC + CT | 66 (35.7) | 38 (50) | 0.032 | 1.80 ( 1.05-3.10 ) |
| TT | 119 (64.3) | 38 (50) | 1 | ||||||
| rs7750018 | 6 | q24.3 | 146206595 | GRM1 | CC + CT | 43 (23.1) | 19 (25.0) | 0.745 | 1.11 (0.60-2.06) |
| TT | 143 (76.9) | 57 (75.0) | 1 | ||||||
| rs362851 | 6 | q24.3 | 146389448 | GRM1 | CC + CG | 117 (62.9) | 52 (68.4) | 0.397 | 1.28 (0.72-2.25) |
| GG | 69 (37.1) | 24 (31.6) | 1 | ||||||
| rs2300631 | 6 | q24.3 | 146428918 | GRM1 | AA + AG | 135 (72.7) | 57 (75.0) | 0.688 | 1.13 (0.62-2.09) |
| GG | 51 (27.4) | 19 (25.0) | 1 | ||||||
| rs12023603 | 1 | p21.2 | 51466999 | GRM2 | GG + AG | 50 (26.9) | 22 (28.9) | 0.734 | 1.11 (0.61-2.00) |
| AA | 136 (73.1) | 54 (71.1) | 1 | ||||||
| rs1983842 | 1 | p21.2 | 51535259 | GRM2 | GG + AG | 56 (30.1)) | 23 (30.2) | 0.980 | 1.01 (0.56-1.80) |
| AA | 130 (69.9) | 53 (69.8) | 1 | ||||||
| rs802441 | 7 | q21.11 | 86657787 | GRM3 | TT + CT | 51 (27.4) | 23 (30.2) | 0.643 | 1.15 (0.64-2.06) |
| CC | 135 (72.6) | 53 (69.8) | 1 | ||||||
| rs802466 | 7 | q21.11 | 86698122 | GRM3 | CC + CT | 35 (18.8) | 9 (11.8) | 0.171 | 0.58 (0.26-1.27) |
| TT | 151 (81.2) | 67 (88.2) | 1 | ||||||
| rs12704286 | 7 | q21.11 | 86745625 | GRM3 | AA + AG | 60 (33.3) | 27 (38.6) | 0.435 | 1.26 (0.71-2.23) |
| GG | 120 (66.7) | 43 (61.4) | 1 | ||||||
| rs17697415 | 7 | q21.11 | 86772500 | GRM3 | AA + AG | 22 (11.8) | 12 (15.8) | 0.387 | 1.40 (0.65-2.99) |
| GG | 164 (88.2) | 64 (84.2) | 1 | ||||||
| rs1873254 | 6 | p21.31 | 34058712 | GRM4 | AA + AG | 105 (57.4) | 43 (57.3) | 0.995 | 1.00 (0.58-1.72) |
| GG | 78 (42.6) | 32 (42.7) | 1 | ||||||
| rs937039 | 6 | p21.31 | 34075875 | GRM4 | GG + AG | 44 (23.6) | 17 (22.4) | 0.823 | 0.93 (0.49-1.76) |
| AA | 142 (76.4) | 59 (77.6) | 1 | ||||||
| rs1565361 | 6 | p21.31 | 34089248 | GRM4 | CC + CT | 84 (45.2) | 33 (43.4) | 0.797 | 0.93 (0.54-1.60) |
| TT | 102 (54.8) | 43 (56.6) | 1 | ||||||
| rs4106126 | 11 | q14.2 | 88647181 | GRM5 | TT + CT | 43 (23.1) | 18 (23.7) | 0.922 | 1.03 (0.55-1.94) |
| CC | 143 (76.9) | 58 (76.3) | 1 | ||||||
| rs1391878 | 11 | q14.2 | 88713212 | GRM5 | CC + CT | 39 (21.0) | 19 (25.0) | 0.476 | 1.26 (0.67-2.35) |
| TT | 147 (79.0) | 57 (75.0) | 1 | ||||||
| rs12787863 | 11 | q14.2 | 88810547 | GRM5 | AA + AG | 77 (41.4) | 33 (43.4) | 0.763 | 1.09 (0.63-1.86) |
| GG | 109 (58.6) | 43 (56.6) | 1 | ||||||
| rs7126679 | 11 | q14.2 | 89020677 | GRM5 | AA + AG | 109 (59.9) | 48 (64.0) | 0.539 | 1.19 (0.68-2.08) |
| GG | 73 (40.1) | 27 (36.0) | 1 | ||||||
| rs2856354 | 5 | q35.3 | 178978728 | GRM6 | GG + AG AA | 81 (43.6) | 37 (48.7) | 0.448 | 1.23 (0.72-2.10) |
| 105 (56.4) | 39 (51.3) | 1 | |||||||
| rs10464073 | 5 | q35.3 | 178982284 | GRM6 | GG + AG | 81 (43.6) | 37 (48.7) | 0.448 | 1.23 (0.72-2.10) |
| AA | 105 (56.4) | 39 (51.3) | 1 | ||||||
| rs17078880 | 5 | q35.3 | 178983436 | GRM6 | TT + CT | 51 (27.7) | 20 (26.7) | 0.863 | 0.95 (0.52-1.74) |
| CC | 133 (72.3) | 55 (73.3) | 1 | ||||||
| rs2645341 | 5 | q35.3 | 178984314 | GRM6 | GG + AG | 53 (28.5) | 19 (25.0) | 0.565 | 0.84 (0.45-1.54) |
| AA | 133 (71.5) | 57 (75.0) | 1 | ||||||
| rs6764411 | 3 | p26.1 | 7101864 | GRM7 | CC + AC | 127 (68.3) | 52 (68.4) | 0.982 | 1.01 (0.57-1.79) |
| AA | 59 (31.7) | 24 (31.6) | 1 | ||||||
| rs17697928 | 3 | p26.1 | 7326084 | GRM7 | AA + AG | 130 (69.9) | 48 (63.2) | 0.289 | 0.74 (0.42-1.29) |
| GG | 56 (30.1) | 28 (36.8) | 1 | ||||||
| rs779741 | 3 | p26.1 | 7541915 | GRM7 | CC + AC | 124 (66.7) | 48 (63.2) | 0.587 | 0.86 (0.49-1.50) |
| AA | 62 (33.3) | 28 (36.8) | 1 | ||||||
| rs1354405 | 3 | p26.1 | 7690304 | GRM7 | GG + AG | 103 (55.4) | 38 (50.0) | 0.428 | 0.81 (0.47-1.38) |
| AA | 83 (44.6) | 38 (50.0) | 1 | ||||||
| rs712723 | 7 | q31.33 | 126439090 | GRM8 | CC + CT | 115 (61.8) | 59 (77.6) | 0.014 | 2.14 ( 1.16-3.6 ) |
| 1 | |||||||||
| rs17627206 | 7 | q31.33 | 126793483 | GRM8 | TT AA + AG | 71 (38.2) 20 (10.7) | 17 (22.4) 8 (10.5) | 0.957 | 0.98 (0.41-2.32) |
| GG | 166 (89.3) | 68 (89.5) | 1 | ||||||
| rs11563505 | 7 | q31.33 | 127059729 | GRM8 | TT + CT | 46 (24.7) | 19 (25.0) | 0.964 | 1.01 (0.55-1.88) |
| CC | 140 (75.3) | 57 (75.0) | 1 | ||||||
Physical position of individual SNPs was based on the NCBI Assembly database: GRCH38 version.
GRIK, glutamate receptor, ionotropic, kainate; GRIA, glutamate receptor, ionotropic, AMPA; GRM, glutamate receptor, metabotropic, SNP, single nucleotide polymorphism; CI, confidence interval.
p-values were obtained by chi-square test (2 x 2 table).
Bold italic are significant at p value <0.05.