Table 1.
Summary of the model parameter values for the targets and organs-at-risk involved in the investigated cancer type. D50 is the 50% response dose, γ is the maximum normalized value of the dose-response gradient and s is the relative seriality, which characterizes the volume dependence of the organ.
| Structure | D50 (Gy) | γ | s | α/β | Endpoint |
|---|---|---|---|---|---|
| Target Volume | 41.7 | 2.2 | — | 10.0 | control |
| Rectum | 80.0 | 2.2 | 0.7 | 3.0 | necrosis, stenosis |
| Bladder | 80.0 | 3.0 | 0.18 | 3.0 | symptomatic contracture |
| Small intestine | 53.6 | 2.3 | 1.5 | 3.0 | obstruction perforation |
| Femur | 65.0 | 2.7 | 1.0 | 3.0 | necrosis |