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. Author manuscript; available in PMC: 2015 Dec 5.
Published in final edited form as: Circ Res. 2014 Oct 20;115(12):976–985. doi: 10.1161/CIRCRESAHA.116.304475

Figure 4. NFATc3 KO Attenuates GRK5-Mediated Cardiac Pathology After Pressure-Overload Stress.

Figure 4

(A) Heart weight to body weight ratio (B) ejection fraction as determine by echocardiography (C) left ventricular internal chamber dimension during diastole (LVIDd) as determined by echocardiography of WT, TgGRK5, NFATc3 KO, TgGRK5/NFATc3 KO mice 1 week after TAC or SHAM. (WT SHAM n=8, WT TAC n=9, TgGRK5 SHAM n=11, TgGRK5 TAC n=11, NFATc3 KO SHAM n=10, NFATc3 KO TAC n=9, TgGRK5xNFATc3 KO SHAM n=7, TgGRK5xNFATc3 KO TAC n=7. *, p<0.05; ** p<0.01; ***, p<0.001 by t test). (D) Cardiomyocyte cross-sectional area. (n=3 hearts per group with a minimum of 50 cells measured per heart. *, p<0.05; ***, p<0.001 by t test). (E) Quantitative RT-PCR for genes Acta-1, β-MHC, CTGF, RCAN from whole heart of the above double transgenic mice.