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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: J Immunother. 2015 Jan;38(1):1–11. doi: 10.1097/CJI.0000000000000062

Figure 3. Cy/GVAX combined with PD-1 blockade increases CD8+ T cells in PDAs.

Figure 3

(A) Schema of immune analysis following tumor implantation by the hemispleen procedure and treatment with Cy (100 mg/kg) on day 3, GVAX on day 4, 7 and IgG/αPD-1/αPD-L1 (5 mg/kg IP) on day 3, 6, 10. Each experimental group consisted of five mice, pooled and analyzed individually in triplicates. Percentage of (B) CD8+ and (C) CD4+ tumor infiltrating lymphocytes among total lymphocytes in murine livers and total numbers of (D) CD8+ and (E) CD4+ tumor infiltrating lymphocytes after Panc02 hemispleen and indicated therapy. Data represent mean ± SEM from one representative experiment that was repeated at least twice. * p=0.04, TIL tumor-infiltrating lymphocytes.