Table 4.
Association of APOE-E4 Allele Status With Each Pure Tone Hearing Threshold.a
| Better ear pure tone hearing threshold β (95% CI) | |||||
|---|---|---|---|---|---|
| 0.5 kHz | 1.0 kHz | 2.0 kHz | 4.0 kHz | 8.0 kHz | |
| All participants (N = 1833) | |||||
| E4 (−/−, n=)b, N = 1340 | Ref | Ref | Ref | Ref | Ref |
| E4 (+/−)b, N = 470 | −0.64 (−2.28 to 1.01) | −1.05 (−2.91 to 0.81) | −1.35 (−3.38 to 0.68) | −2.72 (−4.85 to −0.58)c | −3.05 (−5.22 to −0.87)d |
| E4 (+/+)b, N = 23 | −4.65 (−11.07 to 1.77) | −8.56 (−15.80 to −1.32)c | −6.77 (−14.71 to 1.16) | −5.90 (−14.24 to 2.45) | −2.81 (−11.31 to 5.69) |
| Black (N = 575) | |||||
| E4 (−/−)b, N = 370 | Ref | Ref | Ref | Ref | Ref |
| E4 (+/−)b, N = 194 | −2.65 (−5.32 to 0.01) | −2.98 (−5.87 to − 0.09)c | −2.53 (−5.59 to 0.53) | −3.72 (−7.09 to −0.35)c | −3.61 (−7.39 to 0.17) |
| E4 (+/+)b, N = 11 | −7.33 (−16.55 to 1.88) | −9.53 (−19.52 to 0.45) | −10.85 (−21.43 to −0.28)c | −10.08 (−21.73 to1.57) | −6.67 (−19.72 to 6.38) |
| White (N = 1258) | |||||
| E4 (−/−)b, N = 970 | Ref | Ref | Ref | Ref | Ref |
| E4 (+/−)b, N = 276 | −0.57 (−2.66 to 1.51) | −1.00 (−3.40 to 1.40) | −0.87 (−3.54 to 1.80) | −0.65 (−3.34 to 2.04) | −1.58 (−4.23 to 1.06) |
| E4 (+/+)b, N = 12 | −3.26 (−12.11 to 5.60) | −8.65 (−18.86 to 1.56) | −2.41 (−13.77 to 8.95) | 1.41 (−10.03 to 12.86) | 3.72 (−7.52 to 14.97) |
| Men (N = 878) | |||||
| E4 (−/−, n=)b, N = 653 | Ref | Ref | Ref | Ref | Ref |
| E4 (+/−)b, N = 213 | −1.14 (−3.58 to 1.31) | −0.72 (−3.60 to 2.16) | −0.56 (−3.81 to 2.70) | −1.01 (−4.05 to 2.03) | −1.94 (−5.07 to1.19) |
| E4 (+/+)b, N = 12 | −2.74 (−11.74 to 6.27) | −9.06 (−19.68 to 1.56) | −6.24 (−18.24 to 5.75) | −0.77 (−11.98 to 10.44) | 2.45 (−9.10 to 13.99) |
| Women (N = 955) | |||||
| E4 (−/−, n=)b, N = 687 | Ref | Ref | Ref | Ref | Ref |
| E4 (+/−)b, N = 257 | −0.87 (−3.03 to 1.29) | −1.80 (−4.20 to 0.60) | −2.09 (−4.59 to 0.42) | −3.66 (−6.36 to −0.97)d | −4.10 (−7.12 to−1.09)d |
| E4 (+/+), N = 11 | −6.12 (−15.00 to −2.75) | −7.59 (−17.49 to 2.31) | −7.40 (−17.73 to 2.94) | −12.17 (−23.31 to −1.03)c | −8.53 (−20.99 to 3.94) |
Abbreviations: APOE, apolipoprotein E; CI, confidence interval; Ref, reference; E4 (−/−), Individuals with 0 E4 alleles; E4 (−/+), individuals with 1 E4 allele; E4 (+/+), individuals with 2 E4 alleles.
a Adjusted for age, sex, race, education, study site, diabetes, smoking status, hypertension, stroke, and total fasting cholesterol.
b Negative values indicate better hearing thresholds compared to individuals with 0 E4 alleles (reference).
c P < .05.
d P < .01 compared to individuals with 0 E4 alleles.