Table 4.

Antipsychotic response to CATIE drugs segmented by number of copies of haplotype 2

	0a			1a			2a
Treatment	N	Meanb	SDc	N	Meanb	SDc	N	Meanb	SDc	ADd	Dome	Recf
Olanzapine	69	−15.7	14.7	57	−10.7	11.9	18	−10.2	9.5	0.03	0.02	0.33
Perphenazine	38	−4.4	10.5	29	−14.2	14.6	11	−11.4	10.4	0.01	0.001	0.51
Quetiapine	74	−6.7	10.6	56	−5.0	13.7	11	4.4	13.2	0.02	0.11	0.007
Risperidone	60	−9.3	15.3	67	−9.9	13.6	16	−11.2	10.3	0.66	0.74	0.68
Ziprasidone	34	−2.5	13.0	44	−4.1	10.0	13	−8.1	9.6	0.15	0.31	0.16
Grand Total	275	−8.7	13.8	253	−8.5	13.2	69	−7.9	11.6	NS

^aNumber of copies of the haplotype present in a given subject

^bMean of predicted delta PANSS from the Response model

^cStandard deviation of the mean

^dP-value for the additive genetic model

^eP-value for the dominant genetic model - (0 copies) versus (1 Copy + 2 copies)

^fP-value for the recessive model genetic model - (0 copies + 1 Copy) vs 2 copies