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Comparative summary of melanomagenesis and macrometastasis in LSL-Ras-driven models.
| Genotype | Tumors/Treated Mice (%) |
Median Tumor Latency (wks) |
Macrometastasis |
|---|---|---|---|
| Tp | 1/24 (4.1%) | > 80 | None |
| TpN12D/12D | 1/29 (3.4%) | > 80 | None |
| TpN61R/61R | 14/20 (70%) | 26.3 | None |
| TpK12D/WT | 16/21 (76%) | 36.3 | None |
| TpLN61R/61R | 17/20 (85%) | 22.1 | 5/14 (36%) |
