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. Author manuscript; available in PMC: 2015 Jul 15.
Published in final edited form as: Clin Cancer Res. 2014 Jun 6;21(2):329–334. doi: 10.1158/1078-0432.CCR-14-0508

Figure 1. Asparaginase-related acute complications in childhood ALL in relation to tandem repeat polymorphism and resulting haplotypes in asparaginase synthase (ASNS) gene.

Figure 1

A. Tandem repeat polymorphism in relation to allergies and pancreatitis in ALL patients of discovery cohort. The frequency of individuals with genotypes of tandem repeat polymorphism in patients with (+, dark gray bars) and without (−, light gray bars) allergies and pancreatitis (left and right side panel, respectively). Numbers of individuals represented by each bar, p value for the difference across genotype groups and risk associated with 3R3R genotype (odds ratio, OR, with 95% confidence interval, CI) are indicated on each plot.

B. Risk of allergies and pancreatitis in relation to ASNS haplotypes. Linear display of risk (OR with 95% CI) associated with haplotype *1 and *2 in discovery (QcALL) and replication group (DFCI) based on C-181T substitution (rs3757676) and tandem repeat polymorphism (rs3832526). Protective effect of haplotype *1 in DFCI group was more apparent against local allergies (LA) and in high risk (HR) group. Sequence and frequency of 3 major haplotypes are indicated in the box on the right-bottom side.