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Structural hierarchy of skeletal muscle. Skeletal muscle is composed of bundles of muscle fibers called fascicles. Individual fibers in these fascicles consist of myofibrils, which are composed of the contractile proteins actin and myosin. Connective tissue, which surrounds the muscle at many levels, is organized into epimysium, surrounding the whole muscle; perimysium, surrounding fascicles; and endomysium, surrounding muscle fibers.
