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. Author manuscript; available in PMC: 2015 Dec 4.
Published in final edited form as: Cell. 2014 Dec 4;159(6):1377–1388. doi: 10.1016/j.cell.2014.10.054

Figure 7. Composite Model of Nucleosomal Arrays at Genes.

Figure 7

The nucleosome-free promoter region (5’ NFR) is depicted with RNA polymerase II. Within arrays, the two sides of a nucleosome are depicted as two-toned gray disks, fused to form nucleosomes. In the upper panel, histone marks, variants, and WW/SS dinucleotide enrichment are depicted by different colors. “K9ac”, “ub”, “K4”, and “36” denote H3K9ac, H2Bub, H3K4me3, and H3K36me3, respectively. These features are placed at their predominant locations within arrays. The lower panel illustrates longer WW-rich linkers (red) that are linked to histone destabilization on the linker-flanking half of each nucleosome (symbolized by transparency). The red arrows indicate that those (sub)nucleosomes are closer than normal to their adjacent nucleosomes.