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Effects of CaM antagonists on human multiple myeloma cell proliferation. (A) The basal protein expression levels of CaM in the multiple myeloma cell lines RPMI 8226, U266, MM1.S, MM1.R, NCI-H929, KMS-12-BM, and KMS-5 were determined by western blot analysis. (B) Cells were treated with 0–80 μM W-5, W-7, and W-13 for 24 h, after which cell proliferation was assayed according to the WST-8 method.
