Table 3.

Performance of multivariable models for predicting 28-day mortality in septic patients

	Variable	Cutoff	Sensitivity, %	Specificity, %	PPV, %	NPV, %
28-day mortality	NGAL, ng/mL	236.62	71.80	77.10	79.50	74.50
	MMP-9, ng/mL	95.29	55.30	83.80	43.80	89.20
	TIMP-1, ng/mL	268.27	74.10	88.40	72.10	87.90
	MMP-9/TIMP-1 ratio	0.401	47.70	77.80	20.90	92.40
	PCT, ng/mL	4.27	64.30	84.10	65.20	84.10

NGAL, neutrophil gelatinase-associated lipocalin; MMP-9, matrix metalloproteinase-9; TIMP-1, tissue inhibitor of matrix metalloproteinase-1; PCT, procalcitonin;

NPV, negative predictive value; PPV, positive predictive value.