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. 2014 Dec 2;19(1):68. doi: 10.1186/s40001-014-0068-2

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© Pan et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Clinicopathological impact of miR-148a expression in hepatocellular carcinoma (HCC) tissues. Total miRNA was extracted from HCC and their paired adjacent noncancerous liver tissues. MiR-148a expression was detected by using real time RT-qPCR and the relevant miR-148a level was calculated as compared to the reference of miR-191 and miR-103 combination. Data were shown as mean ± SD. (A) Different liver tissues; (B) Clinical TNM stages; (C) Metastasis; (D) Tumor capsular infiltration; (E) Tumor nodes. (F) The time-to-recurrence of high expression of miR-148a (higher than the median level) was 61.47 ± 3.45 months, longer than those with low expression (50.56 ± 4.15); however, the difference was not significant (P = 0.238).