Table 2.

Cytotoxicity and anti-MAYV activity of EtOAc, n-BuOH and EtOAc-Pp fractions

Substance	CC 50 (μg/mL) a	CC 90 (μg/mL) a	IC 50 (μg/mL) b	IC 90 (μg/mL) b	SI c	RP d
n-BuOH	2614 ± 366	821 ± 115	7,1 ± 1,0	40,9 ± 5,7	20	10
EtOAc	457,7 ± 9,5	176,1 ± 3,5	8,2 ± 0,2	89,1 ± 4,4	2	1
EtOAc-Pp	324,1 ± 6,5	154,7 ± 3,1	2,5 ± 0,1	4,7 ± 0,3	33	16,5
ribavirin	523,1 ± 42,5	215,4 ± 6,2	62,3 ± 4,4	112,4 ± 8,2	2	nd

^a50% and 90% cytotoxic concentration.

^b50% and 90% inhibitory concentration of viral replication.

^cSelectivity Index = standard IC₉₀/substance IC_90.

^dRelative Potency = ratio between ribavirin (reference substance) IC₉₀ and the tested substance’s IC₉₀.

nd – Not determined.