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. 2014 Dec 4;7:29. doi: 10.1186/1756-8935-7-29

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© Shah et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Average over-/underexpression frequencies and mutation rates of chromatin factor families. Top: Averages were calculated by summing the frequencies of overexpression or underexpression, or number of mutations per kilobase for each gene and dividing by the total number of genes in the family. The list of 359 chromatin factors is composed of the 441 genes listed in Additional file 1: Table S1 from which histones and histone chaperones were removed. Numbers were also calculated for five independent sets of 359 random genes for comparison. Log2(mRNA tumor/matched control) cut-offs of 2 and -2 were used for over- and underexpression, respectively, for better separation and comparison of transcription profiles.