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. 2014 Dec 4;7:29. doi: 10.1186/1756-8935-7-29

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© Shah et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Correlation between mRNA expression and copy number variation. (A-F) Recurrence of gene overexpression in tumor samples across different cancer types (blue bars - log2(mRNA(tumor/matched normal)) >1) compared with recurrence of gene amplification (red bars - GISTIC =2 and log2(mRNA(tumor/matched normal)) >1). (C-F) Box plots distribution of changes in gene expression levels (log2(mRNA(tumor/matched normal))) in tumor samples grouped by GISTIC values (that is, levels of copy number variation).