Table IV.

Summary statistics for six specifications of the proposed design.

	Scenario
Design specifications	1	2	3	4	5	6
	Proportion stopped for safety
$p_i^{*},q_i^{*}$, ψ = 0, nR = 20	0.000	0.000	0.000	0.000	0.000	0.721
$p_i^{*},q_i^{*}$, ψ = −2.049, nR = 20	0.000	0.000	0.000	0.000	0.000	0.714
$p_i^{*},q_i^{*}$, ψ = 0.814, nR = 20	0.000	0.000	0.000	0.000	0.000	0.733
$p_i^{**},q_i^{**}$, ψ = 0, nR = 20	0.000	0.000	0.000	0.000	0.000	0.722
$p_i^{*},q_i^{*}$, ψ = 0, nR = 10	0.000	0.000	0.000	0.000	0.001	0.684
$p_i^{*},q_i^{*}$, ψ = 0, nR = 30	0.000	0.000	0.000	0.000	0.001	0.701
	Proportion stopped for futility
$p_i^{*},q_i^{*}$, ψ = 0, nR = 20	0.049	0.055	0.025	0.013	0.017	0.000
$p_i^{*},q_i^{*}$, ψ = −2.049, nR = 20	0.040	0.053	0.031	0.023	0.032	0.000
$p_i^{*},q_i^{*}$, ψ = 0.814, nR = 20	0.043	0.037	0.030	0.011	0.025	0.000
$p_i^{**},q_i^{**}$, ψ = 0, nR = 20	0.073	0.095	0.046	0.022	0.057	0.000
$p_i^{*},q_i^{*}$, ψ = 0, nR = 10	0.052	0.070	0.027	0.018	0.035	0.000
$p_i^{*},q_i^{*}$, ψ = 0, nR = 30	0.030	0.023	0.010	0.010	0.022	0.000
	Observed DLT rate
$p_i^{*},q_i^{*}$, ψ = 0, nR = 20	0.116	0.177	0.212	0.245	0.248	0.512
$p_i^{*},q_i^{*}$, ψ = −2.049, nR = 20	0.113	0.175	0.211	0.249	0.247	0.511
$p_i^{*},q_i^{*}$, ψ = 0.814, nR = 20	0.115	0.174	0.211	0.244	0.247	0.516
$p_i^{**},q_i^{**}$, ψ = 0, nR = 20	0.118	0.175	0.214	0.241	0.242	0.508
$p_i^{*},q_i^{*}$, ψ = 0, nR = 10	0.127	0.189	0.225	0.257	0.255	0.507
$p_i^{*},q_i^{*}$, ψ = 0, nR = 30	0.104	0.163	0.201	0.235	0.237	0.511
	Observed response rate
$p_i^{*},q_i^{*}$, ψ = 0, nR = 20	0.256	0.272	0.340	0.411	0.399	0.508
$p_i^{*},q_i^{*}$, ψ = −2.049, nR = 20	0.256	0.271	0.342	0.411	0.402	0.503
$p_i^{*},q_i^{*}$, ψ = 0.814, nR = 20	0.259	0.267	0.343	0.419	0.400	0.509
$p_i^{**},q_i^{**}$, ψ = 0, nR = 20	0.264	0.271	0.340	0.406	0.389	0.507
$p_i^{*},q_i^{*}$, ψ = 0, nR = 10	0.283	0.290	0.361	0.427	0.414	0.507
$p_i^{*},q_i^{*}$, ψ = 0, nR = 30	0.230	0.251	0.323	0.399	0.381	0.510

Combinations with acceptable toxicity (i.e., ≤ ϕ_T = 30%) and high efficacy (i.e., ≥ ϕ_E = 30%) are defined as ‘target combinations’.

$p_i^{*}=\mathtt{\text{getprior}}(0.045,0.30,5,9);q_i^{*}=\mathtt{\text{getprior}}(0.045,0.50,5,9),p_i^{**}=\mathtt{\text{getprior}}(0.06,0.30,4,9);q_i^{**}=\mathtt{\text{getprior}}(0.06,0.50,4,9).$