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. Author manuscript; available in PMC: 2015 Dec 15.
Published in final edited form as: Arch Biochem Biophys. 2014 Sep 18;0:89–99. doi: 10.1016/j.abb.2014.09.007

Figure 4.

Figure 4

Histograms revealing changes in Coulombic binding interactions between tropomyosin and actin due to tropomyosin mutations associated with hyper-contractility. Differences in electrostatic binding interaction surrounding the energy minimum site (averaged over an approximately 16 Å2 region as indicated by white squares in Figure 2) between wild-type and mutant tropomyosin landscapes quantified by subtracting one from the other. The positive values noted indicate a decrease in strength of binding by the mutants.