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. Author manuscript; available in PMC: 2015 Dec 15.
Published in final edited form as: J Immunol. 2014 Nov 5;193(12):6050–6060. doi: 10.4049/jimmunol.1401746

Figure 2. mAb blocking of Type I IFN signaling prevents the Bbaa1 dependent increase in arthritis in B. burgdorferi infected mice.

Figure 2

B6.C3-Bbaa1 mice were treated with 2.5 mg MAR1-5A3 blocking mAb or isotype control the day before infection. Congenic and parental B6 and C3H mice were infected with B. burgdorferi and arthritis severity analyzed at 4 wks. of infection, shown for (A) Change in ankle measurement and (B) Overall lesion score. Statistical significance was determined by Student’s t-test for ankle swelling while the Mann Whitney U test was used for Overall lesion. n=5 per group.