Table 1.
Subject Characteristics
| High Risk for Bipolar Disorder (N=12) | Archived Healthy Controls (N=12) | p | |
|---|---|---|---|
| Age, mean (SD) | 13.55 (3.40) | 13.59 (3.01) | .98 |
| Full scale IQ, mean (SD) | 110.50 (10.5) | 112 (9.3) | .72 |
| Female/Male | 8 male and 4 female | 8 male and 4 female | same |
| Right handed / Left handed Or ambidextrous | 9 right, 2 left, 1 ambidextrous | 11 right and 1 left | .47 |
| Faces Task Accuracy (percent correct; mean (SD) | 95.9 (5.6) | 95.6 (5.8) | .89 |
| Faces Task Response Time (milliseconds, mean (SD) | 883.5 (137.9) | 828.14 (170.60) | .39 |
| Diagnoses (number out of 12) | |||
| BD NOS | 5 | - | - |
| MDD | 7 | - | - |
| ADHD | 6 | - | - |
| Anxiety disorder | 6 | - | - |
| CD or ODD | 3 | - | - |
| Cyclothymia | 1 | - | - |
| Medication* | 6 | - | - |
| CDRS pre-treatment mean (SD) | 39.08 (5.8) | - | - |
| CDRS post-treatment mean (SD) | 34.08 (8.6) | - | - |
| YMRS pre-treatment mean (SD) | 13.42 (5.5) | - | - |
| YMRS post-treatment mean (SD) | 9.67 (5.3) | - | - |
*
Medications at Baseline: 1 taking divalproex, aripiprazole and a stimulant, 2 taking lithium; 1 taking a stimulant, 1 taking aripiprazole, a stimulant and antidepressant, 1 taking antidepressant. Changes in medication during treatment: 1 added an anti-anxiety medication by end of treatment, 1 added lamotrigine and an antidepressant by visit 3; 1 added ziprasidone and an antidepressant by end of treatment; 1 added risperidone by visit 2; 1 stopped taking antidepressants by month 3 of treatment.