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Aging and an obesigenic diet can alter microglia phenotype, rendering them more sensitive to various insults. Consuming a diet rich in flavonoid and non-flavonoid bioactives and n-3 PUFAs can inhibit microglia and thereby reduce neuroinflammation. Abbreviations: ARE, anti-oxidant response element; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; PUFA, polyunsaturated fatty acid.
