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Model for pRB:CBP:E7 ternary complex formation. E7 dimerization through the CR3 domain facilitates recruitment of CBP/p300 to pRb. The LxCxE motif of one of the E7 monomer units interacts with the pRb B domain, while the other mediates a ternary interaction with the TAZ2 domain of CBP/p300 and pRb-B, bringing the HAT domain of CBP/p300 close to the pRb C-terminal region and enabling acetylation at pRb lysines 873 and 874.
