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. Author manuscript; available in PMC: 2016 Jan 1.

Published in final edited form as: Ultrasound Med Biol. 2014 Nov 15;41(1):187–196. doi: 10.1016/j.ultrasmedbio.2014.08.018

The absolute lytic rate ( $| Δ \bar{d} / Δt |$ ) as a function of the RMS velocity of the clot at each concentration of recombinant tissue-type plasminogen activator (rt-PA). The lytic rate was computed using Equation (1), with t₂ − t₁ = 0.43 s, the interframe time of the clot images. Similarly, the RMS velocity of the clot was computed using Equation (2), with t₂ − t₁ = 0.43 s. The error bars are representative of the standard deviation of the lytic rate over a 0.41 μm/s range of RMS velocities. (a) Insonation of rt-PA and Definity^®. The lytic rate significantly correlates (p < 0.05) with the RMS velocity when rt-PA is present. (b) Insonation of rt-PA alone. The lytic rate significantly correlates (p < 0.05) with the RMS velocity at all concentrations of rt-PA.

The absolute lytic rate ( $| Δ \bar{d} / Δt |$ ) as a function of the RMS velocity of the clot at each concentration of recombinant tissue-type plasminogen activator (rt-PA). The lytic rate was computed using Equation (1), with t₂ − t₁ = 0.43 s, the interframe time of the clot images. Similarly, the RMS velocity of the clot was computed using Equation (2), with t₂ − t₁ = 0.43 s. The error bars are representative of the standard deviation of the lytic rate over a 0.41 μm/s range of RMS velocities. (a) Insonation of rt-PA and Definity^®. The lytic rate significantly correlates (p < 0.05) with the RMS velocity when rt-PA is present. (b) Insonation of rt-PA alone. The lytic rate significantly correlates (p < 0.05) with the RMS velocity at all concentrations of rt-PA.