Figure 6.

LIMK1 expression is decreased in the preeclampsia setting in utero. Early third trimester human placental samples obtained from women diagnosed with severe preeclampsia (sPE) were compared with placental samples obtained from gestational age matched samples obtained from women who delivered due to normal preterm labor (nPTL) without overt signs of clinical infection. A: Immunofluorescence microscopy-based approaches indicate that although invasive CTBs and cCTBs in nPTL placentas exhibit robust LIMK1 immunoreactivity, the expression of LIMK1 is frequently decreased in the sPE setting in vivo. B: Immunoblot analysis of CTB lysates derived from additional nPTL and sPE placentas. C: Densitometric analysis of relative expression levels of LIMK1 in B.