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. 2014 Dec;184(12):3176–3191. doi: 10.1016/j.ajpath.2014.08.021

Figure 1.

Figure 1

Bioluminescence increased with induction of prostatitis. A: A schematic shows the two major mouse models that were crossed for this study: the C57/Luc/Pten−/− model of prostate carcinogenesis that contains Cre recombinase driven by the prostate-specific promoter probasin, luciferase expression in the prostate; and prostate-specific inactivation of Pten was crossed with the POET-3 model, allowing for controlled induction of autoimmune prostatitis. B: Experimental timeline shows ages of treatments and timing of tissue harvests. C: Bioluminescence of P3+Pten+/+ mice increased transiently after induction of prostatitis. D: Bioluminescence increased in the weeks after induction of prostatitis in P3+Pten+/− mice. Data are expressed as means ± SEM (C and D). n = 12 to 14 early time points (C); n = 4 later time points (C); n = 15 to 22 early time points (D); n = 4 to 5 later time points (D). ∗∗P < 0.01, ∗∗∗P < 0.001, and ∗∗∗∗P < 0.0001, Student's t-test.