Table 10.

Female/male geometric LS mean total exposure (AUC_0–t) ratios and the 90% CI of R-(+)- and S-(−)-ALA enantiomers by treatment

R-(+) AUC ratios LS and CI				S-(−) AUC ratios LS and CI
Treatment	Point estimate (%)	90% CI		Point estimate (%)	90% CI
		Lower (%)	Upper (%)		Lower (%)	Upper (%)
OS	141.15	114.39	174.16	143.77	115.75	178.57
T 200	141.01	110.04	180.68	142.68	112.37	181.17
T 300	134.85	110.61	164.41	141.68	113.81	176.38
T 600	142.02	114.90	175.72	148.75	117.06	189.01

Abbreviations: AUC, area under the curve; LS, least squares; CI, confidence interval; OS, orally administered ALA solution; T 200, 200 mg tablet; T 300, 300 mg tablet; T 600, 600 mg tablet; ALA, alpha-lipoic acid.