Table 4.
Dysregulated Genes in Altered Pathways
| Gene symbol | Gene name | FC | ECM-receptor interaction | Dilated cardiomyopathy | Focal adhesion | ARVC | TGF-β signaling pathway | Vascular smooth muscle contraction | Hedgehog signaling pathway | Regulation of actin cytoskeleton | Calcium signaling pathway |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cacna1d | Calcium channel, L-type α1D subunit | 1.6 | • | • | • | • | |||||
| Prkch | Protein kinase C, η | 1.9 | • | ||||||||
| Adra1d | Adrenergic receptor α1d | 0.6 | • | • | |||||||
| Ppp1r14a | Protein phosphatase 1, regulatory subunit 14A | 1.7 | • | ||||||||
| Kcnma1 | Potassium large-conductance calcium-activated, M, α member 1 | 1.9 | • | ||||||||
| Pla2g4a | Phospholipase A2, group IVA | 2.0 | • | ||||||||
| Adora2b | Adenosine A2b receptor | 1.8 | • | • | |||||||
| Avpr1a | Arginine vasopressin receptor 1A | 3.5 | • | • | |||||||
| Ramp1 | Receptor G-protein–coupled, activity-modifying protein 1 | 1.8 | • | ||||||||
| Itgα3 | Integrin α3 | 1.7 | • | • | • | • | • | ||||
| Itgα4 | Integrin α4 | 1.6 | • | • | • | • | • | ||||
| Itgα8 | Integrin α8 | 1.8 | • | • | • | • | • | ||||
| Itgα11 | Integrin α11 | 2.5 | • | • | • | • | • | ||||
| Itgβ6 | Integrin β6 | 1.9 | • | • | • | • | • | ||||
| Lama2 | Laminin, α2 | 1.8 | • | • | • | • | |||||
| Lama5 | Laminin, α5 | 1.7 | • | • | |||||||
| Lamb3 | Laminin, β3 | 1.8 | • | • | |||||||
| Col6a3 | Collagen, type VI, α3 | 1.5 | • | • | |||||||
| Col1a1 | Collagen, type I, α1 | 1.9 | • | • | |||||||
| Col1a2 | Collagen, type I, α2 | 1.7 | • | • | |||||||
| Tnc | Tenascin C | 3.5 | • | • | |||||||
| Thbs1 | Thrombospondin 1 | 1.9 | • | • | • | ||||||
| Thbs2 | Thrombospondin 2 | 2.9 | • | • | • | ||||||
| Npnt | Nephronectin | 1.9 | • | ||||||||
| BclII | B-cell leukemia/lymphoma 2 | 1.6 | • | ||||||||
| Pdgfd | Platelet-derived growth factor D | 2.2 | • | • | |||||||
| Cdh2 | Cadherin 2 | 0.5 | • | ||||||||
| Sgcg | Sarcoglycan, γ | 0.4 | • | • | |||||||
| Dmd | Dystrophin | 2.0 | • | • | |||||||
| Tgfb2 | Transforming growth factor, β2 | 1.7 | • | • | |||||||
| Tgfb3 | Transforming growth factor, β3 | 2.0 | • | • | |||||||
| Bmp2 | Bone morphogenetic protein 2 | 2.0 | • | • | |||||||
| Bmp4 | Bone morphogenetic protein 4 | 2.2 | • | • | |||||||
| Bmp5 | Bone morphogenetic protein 5 | 3.5 | • | • | |||||||
| Ptch1 | Patched homolog 1 | 1.6 | • | ||||||||
| Wnt5a | Wingless-related MMTV integration site family, member 5A | 1.7 | • | ||||||||
| Hhip | Hedgehog interacting protein | 3.1 | • | ||||||||
| Fgf7 | Fibroblast growth factor 7 | 1.8 | • | ||||||||
| Myh10 | Myosin, heavy polypeptide 10, nonmuscle | 1.7 | • | ||||||||
| Itpka | Inositol-trisphosphate 3-kinase A | 0.5 | • | ||||||||
| Slc8a3 | Solute carrier family 8 (sodium/calcium exchanger), member 3 | 1.9 | • | ||||||||
| Ppp3ca | Protein phosphatase 3, catalytic subunit, α isozyme | 1.6 | • | ||||||||
| Igh/Igh-VJ558 | Immunoglobulin heavy chain (J558 family) | 0.3 | • | • | |||||||
| Gna15 | Guanine nucleotide binding protein (G protein), α15 (Gq class) | 1.9 | • | ||||||||
| Ptger1 | Prostaglandin E receptor 1 (subtype EP1) | 1.6 | • | ||||||||
| Ptger3 | Prostaglandin E receptor 3 (subtype EP3) | 0.5 | • |
ARVC, arrhythmogenic right ventricular cardiomyopathy; ECM, extracellular matrix; FC, fold-change; Kegg, Kyoto Encyclopedia of Genes and Genomes database; TGF, transforming growth factor.