Figure 2.

Terminal target organ lesions in cynomolgus macaques challenged with Ames strain Bacillus anthracis by bronchoscopy are similar to those observed after inhalation of aerosolized spores. Terminal lesions were similar regardless of inoculum dose or time to death. Sections were stained with H&E (A–D) and Brown and Brenn stain (E–H). A and E: Alveolar septa in the lungs are distended with bacilli. B and F: Bacilli in the subcapsular sinus and cortex of a tracheobronchial lymph node, with cortical lymphocytolysis. C and G: Numerous bacilli in the splenic red pulp. D and H: Bacilli with scattered neutrophils in the hepatic sinusoids. Arrows point to bacilli. Original magnification: ×400 (A–H).