Table 4.
Quantitative Bacterial Cultures from Tissues of Cynomolgus Macaques Challenged by the I.V. Route with Mixtures of Bacilli of the Ames Strain and the PA Deletion Mutant
| Animal no. | Time to euthanasia (h) | I.V. dose (CFU) |
Concentration (CFU/g) |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Lung |
Spleen |
Liver |
|||||||
| Ames | PA− | WT | PA− | WT | PA− | WT | PA− | ||
| V16 | 24.5 | 6.0 × 104 | 4.0 × 104 | 1.5 × 104 | 4.1 × 103 | 4.2 × 105 | 2.4 × 103 | 1.4 × 104 | BLD |
| V17 | 25.0 | 6.0 × 104 | 4.0 × 104 | BLD | BLD | 6.0 × 103 | 5.8 × 102 | 3.0 × 103 | BLD |
| V18 | 24.5 | 8.0 × 105 | 1.8 × 106 | BLD | BLD | 8.5 × 103 | 8.2 × 102 | BLD | BLD |
| V19∗ | 30.5 | 1.0 × 105 | 1.0 × 105 | 5.3 × 108 | 6.0 × 105 | >1.5 × 109 | 4.5 × 107 | 1.2 × 109 | 2.2 × 107 |
BLD, below limit of detection; PA, protective antigen; WT, wild type.
∗
V19 was the only monkey of this group with clinical signs related to anthrax at the time of euthanasia.