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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Free Radic Biol Med. 2014 Sep 16;0:121–129. doi: 10.1016/j.freeradbiomed.2014.08.023

Figure 1. Model state diagram and ROS leak pathways.

Figure 1

A) The 5-state model is shown with green arrows representing the NADH + H+ + Q ↔ NAD+ + QH2 reaction, blue arrows representing O2 ↔ H2O2 reaction, and red arrows representing the O2 ↔ O2·− reaction. B) For each state, the substates and their possible ROS leak sites are shown as stars (right). Green stars signify the most relevant sites identified after model analysis.