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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Free Radic Biol Med. 2014 Sep 16;0:121–129. doi: 10.1016/j.freeradbiomed.2014.08.023

Figure 5. Model simulation of ROS stoichiometric coefficient, n, NADH oxidation, and ROS production as a function of ΔΨ, matrix pH, %NADH, and %Q.

Figure 5

The ΔΨ and pH are plotted on the main independent axes, and the %NADH and %Q are depicted using a color scheme. The legend for the color scheme is indicated in the figure. Blue indicates high %Q, red indicates high %NADH, magenta indicates both high %Q and %NADH, and black indicates low %Q and %NADH. In A), small points corresponding to forward electron transport (FET) and large circles represent reverse electron transport (RET) operating conditions. FET is defined as NADH-induced reduction of Q. RET is defined as QH2-induced reduction of NAD+. The mesh represents the average value at a given ΔΨ and pH value. In C, JROS is equal to JO2·−/2 + JH2O2. Cytosolic pH was set to 7.1 in all simulations.