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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Biochim Biophys Acta. 2014 Jul 28;1848(0):289–298. doi: 10.1016/j.bbamem.2014.07.022

Figure 1.

Figure 1

(A) Ectodomain of the HIV gp41 protein showing domains including fusion peptide (FP), N-heptad repeat (NHR), loop, C-heptad repeat (CHR), and membrane-proximal external region (MPER). (B, C) Amino acid sequences of the Hairpin (HP) and FP-Hairpin (FP-HP) proteins with color-matching with panel A. The sequences of HP and FP-HP are from the HXB2 laboratory strain of HIV-1. Using gp160 numbering, HP includes [535–581(M535C)]-[SGGRGG]-[628–666] and FP-HP includes [512–581(M535C)]-[SGGRGG]-[628–666]. The first bracket for HP includes much of the NHR for HP and the first bracket for FP-HP includes the full FP and much of the NHR. For both constructs, the third bracket includes much of the CHR. The intervening SGGRGG is a non-native loop shorter than the ~20-residue native loop but still allows formation of a stable hairpin with antiparallel NHR and CHR helices.