Table 3.
fMRI Striatal ROI Analysis in MC4R-Deficient Individuals, Lean and Obese Controls
| Brain Region | P (FWE) | F or T | MNI Coordinates |
||
|---|---|---|---|---|---|
| x | y | z | |||
| Appetizing > non-food | |||||
| Dorsal striatum left (caudate/putamen) | |||||
| Main effect of group | .04 | F = 9.92 | −18 | 14 | 6 |
| MC4R > obese | .01 | T = 4.18 | −18 | 14 | 6 |
| LC > obese | .02 | T = 3.45 | −20 | 14 | 8 |
| Ventral striatum left | |||||
| Main effect of group | .05 | F = 9.25 | −12 | 18 | −12 |
| MC4R > obese | .01 | T = 4.25 | −12 | 20 | −12 |
| LC > obese | .10 | T = 2.87 | −12 | 16 | −12 |
| Appetizing > bland | |||||
| Dorsal striatum left (caudate/putamen) | |||||
| Main effect of group | .07 | F = 7.33 | −14 | 20 | 16 |
| MC4R > obese | .01 | T = 3.81 | −12 | 20 | 16 |
| LC > obese | .03 | T = 3.26 | −16 | 18 | 8 |
Abbreviations: LC, lean controls; FWE, family-wise error; MNI, Montreal Neurological Institute. Statistics and coordinates for analysis of group differences in striatal ROIs (small volume corrected for multiple comparisons). Main effects of group are listed, as well as post hoc t tests.