Table 1.
Summary of PYY and GLP-1 Plasma Concentrations (in pmol/L) and Area Under The Curve Values (pmol · L−1 · min) for Each of the Infusion Arms: Vehicle, PYY3–36, GLP-17–36 amide, and Combination
| Infusion Arm | Baseline Plasma Concentration, pmol/L | End-Infusion Plasma Concentration, pmol/L | AUC Plasma Concentrations Over Infusion Period, pmol · L−1 · min |
|---|---|---|---|
| PYY levels | |||
| Vehicle | 47.7 ± 8.7 | 26.7 ± 15.8 | 2766 ± 423.7 |
| PYY | 45.8 ± 8.1 | 113.5 ± 13.7 | 6091 ± 861.2 |
| GLP-1 | 34.1 ± 5.3 | 21.3 ± 13.9 | 3395 ± 575.9 |
| Combination | 52.2 ± 10.9 | 97.8 ± 37.2 | 7297 ± 1460 |
| GLP-1 levels | |||
| Vehicle | 43.7 ± 6.2 | 44.0 ± 8.5 | 3614 ± 344.2 |
| PYY | 43.8 ± 7.7 | 33.4 ± 2.6 | 3813 ± 458.7 |
| GLP-1 | 55.6 ± 9.7 | 142.2 ± 22.3 | 9084 ± 1134 |
| Combination | 52.6 ± 15.2 | 140.4 ± 22.0 | 8639 ± 1495 |