Figure 3. Reduction in Fos staining following infusion of antisense Fos ODNs.
Photomicrographs show Fos staining following infusion (2.5h earlier) of sense Fos ODN (A and C) or antisense Fos ODN (B and D). The amount infused was 1nmol in 1μl (A and B) and 5nmol in 1μl (C and D). Cell counts confirmed a reduction in Fos staining following the antisense infusions (1nmol: sense count = 260; antisense count = 156); the 5nmol antisense infusion produced a readily visible reduction (sense count = 397; antisense count = 127). Scale bar = 100 μm.