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. Author manuscript; available in PMC: 2014 Dec 8.
Published in final edited form as: Hippocampus. 2012 Apr 25;22(11):2101–2113. doi: 10.1002/hipo.22028

Figure 4. Infusion of antisense Fos ODN disrupts differential Fos expression in the perirhinal cortex.

Figure 4

Fos counts normalised across both brain hemispheres for each brain region are shown for the novel and the familiar hemispheres for sense or antisense ODN-treated rats for the following regions: perirhinal cortex (PRH), temporal association cortex (Te2), auditory cortex (AU) and entorhinal cortex (ENT). Following infusions of sense Fos ODN (control) into the perirhinal cortex there is a differential expression of Fos in response to viewing novel or familiar images in the perirhinal cortex (in agreement with previous studies): repeated measures ANOVA effect of novelty/familiarity: * p < 0.05, ** p < 0.01. After infusion of antisense Fos ODN the differential expression of Fos within the perirhinal cortex is disrupted: repeated measures ANOVA interaction of treatment and novelty/familiarity: †† p < 0.01. In PRH, a significant interaction between novelty/familiarity and ODN treatment was found. In both sense and antisense groups, Fos counts in Te2 were higher in the novel than the familiar hemisphere.