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. Author manuscript; available in PMC: 2014 Dec 8.
Published in final edited form as: Hippocampus. 2012 Apr 25;22(11):2101–2113. doi: 10.1002/hipo.22028

Figure 5. Antisense Fos ODN impairs object recognition memory.

Figure 5

Bilateral perirhinal infusion of sense Fos (control) ODN (light grey) or antisense Fos ODN (dark grey) were made prior to object recognition memory testing. Antisense ODN impaired familiarity discrimination when it was administered before acquisition and the memory delay period was 3 h or 24 h (long-term memory) but not if the memory delay period was 20 min (shorter-term memory). All groups receiving sense Fos ODN infusions showed significant discrimination (DR>0) denoted by O. Within subject ANOVA treatment difference: *** p < 0.001. One-sample t-test of DR value against zero: O p < 0.05. Following administration of sense Fos ODN there was no significant difference between discrimination levels (DR values: ANOVA, p>0.05) for the acquisition experiments described above. The order that the experiments were run was (1) 24h, (2) 20min and (3) 3h. The finding that memory was unimpaired in the second experiment even though it was impaired in the first indicates that the ability to acquire new recognition memories was not permanently impaired by the previous antisense Fos ODN infusion.