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. 2014 Dec 8;4:7306. doi: 10.1038/srep07306

Figure 3. Analysis of inter-residue CCS pairwise correlations reveals the “chaining effect” of single-linkage agglomerative clustering.

Figure 3

(A) Inter-residue pairwise correlation between L221 and K216. Despite the poor K216 vs. L221 correlation, single-linkage clustering assigns L221 and K216 to the same cluster because of a chain of strong correlations that links these two residues together, as shown in panels (B–F). (G) The single-linkage dendrogram for the allosteric residue cluster reveals the branch locations of residues in panels (A–F) (red residues). The black arrows outline the chain of correlations connecting K216 and L221 (dashed rectangles).