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. 2014 Dec 8;4:7306. doi: 10.1038/srep07306

Figure 6. Summary maps of CHESCA-based allosteric ensembles identified for PKA RIα CBD-A.

Figure 6

(A) Structure-based allosteric residues for the folded CBD-A. Residues with a local RMSD between the C-bound and cAMP-bound crystal structures of PKA R (PDB IDs: 3FHI and 3PNA) greater than 1 Å are shown as a blue surface. (B–D) Allosteric residues from the CHESCA-SL, -CL and -I analyses of PKA CBD-A, respectively, mapped onto its crystal structure. cAMP is shown as black spheres.