Enforced expression of RPS19 results in long-term rescue of the hematopoietic defect of Rps19-deficient mice. (A) Experimental strategy to validate the long-term therapeutic potential of RPS19 gene correction. (B) Erythrocyte number, hemoglobin concentration, mean corpuscular volume (MCV), reticulocyte number, white blood cell number and platelet number after 4 months of doxycycline administration (n = 22, 24, 14, 16 and 11 for the Control SFFV-GFP, Control SFFV-RPS19, D/+ SFFV-GFP, D/+ SFFV-RPS19 and D/D SFFV-RPS19, respectively). Error bars represent standard deviation.